• 
  Racing Club – San

  10 December

• 
  Gimnasia LP – Huracan

  9 December

• 
  Godoy – Independiente

  9 December

• 
  Defensa y Justicia – Colon

  8 December

• 
  San – Estudiantes

  8 December

• 
  Union – Banfield

  8 December

• 
  Gent – Eupen

  9 December

• 
  Anderlecht – Charleroi

  9 December

• 
  Cercle Bruges – Antwerp

  9 December

• 
  Sint-Truiden – Standard

  8 December

• 
  Ostend – Lokeren

  8 December

• 
  Mouscron-Peruwelz – Zulte-Waregem

  8 December

• 
  Racing Genk – Kortrijk

  8 December

• 
  Junior – Independiente M

  9 December

• 
  Sparta Praha – Teplice

  9 December

• 
  Slavia Praha – Mlada

  8 December

• 
  Liga de Quito – Delfin

  8 December

• 
  Newcastle – Wolverhampton

  9 December

• 
  Leicester – Tottenham

  8 December

• 
  Chelsea – Manchester

  8 December

• 
  Lille – Reims

  9 December

• 
  Strasbourg – Caen

  9 December

• 
  Rennes – Dijon

  8 December

• 
  Guingamp – Amiens

  8 December

• 
  Moenchengladbach – Stuttgart

  9 December

• 
  Mainz – Hanover

  9 December

• 
  Hertha – Eintracht

  8 December

• 
  PAOK – Larisa

  9 December

• 
  Atromitos – Aris

  9 December

• 
  OFI – Panathinaikos

  9 December

• 
  Skoda – Olympiacos

  9 December

• 
  AEK – Lamia

  8 December

• 
  Milan – Torino

  9 December

• 
  Genoa – SPAL

  9 December

• 
  Udinese – Atalanta

  9 December

• 
  Parma – Chievo

  9 December

• 
  Empoli – Bologna

  9 December

• 
  Sassuolo – Fiorentina

  9 December

• 
  Lazio – Sampdoria

  8 December

• 
  Cagliari – Roma

  8 December

• 
  Amur – Barys

  10 December

• 
  CSKA Moscow – Salavat

  9 December

• 
  America – UNAM

  10 December

• 
  Breda – Vitesse

  9 December

• 
  Emmen – Feyenoord

  9 December

• 
  Venlo – Groningen

  9 December

• 
  Utrecht – Heracles

  9 December

• 
  Den Haag – De Graafschap

  8 December

• 
  Zwolle – Ajax

  8 December

• 
  Willem II – Heerenveen

  8 December